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Enantioseparation in capillary electrophoresis using
发布:北京华阳利民仪器有限公司浏览次数:499The resolving ability of 2-O-(2-hydroxybutyl)- -CD (HB- -CD) with different degrees of substitution (DS = 2.9 and 4.0) as a chiral selector in CZE is reported in this work. Fourteen chiral drugs belonging to different classes of compounds of pharmaceutical interest such as -agonists, antifungal agents, ageneric agents, etc., were resolved. The effects of the DS of HB- -CD on separations were also investigated. The chiral resolution (Rs) was strongly influenced by the concentrations of the CD derivative, the BGE, and the pH of the BGE. Under the conditions of 50 mmol/L Tris-phosphate buffer at pH 2.5 containing 5 mmol/L HB- -CD, all 14 analytes were separated. The very low concentration necessary to obtain separation was particularly impressive. The DS had a significant effect on the resolution of the chiral drugs and the ionic strength of the separation media; hence, the use of a well-characterized CD derivative is crucial. GX毛细管电泳仪(紫外检测)CL1030
2007-06-18上一篇:Capillary zone electrophoretic chiral discrimination
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