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仪器网/ 行业应用/ 解决方案/ SPDE技术与质谱结合测定头发中毒品含量

SPDE技术与质谱结合测定头发中毒品含量

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利用HS-SPDE/GC/MS/MS技术测定头发中毒品含量A new method combination, headspace solid-phase dynamic extraction coupled with gas chromatography/
tandem mass spectrometry (HS-SPDE/GC/MS/MS), is introduced to determine drugs of
abuse in hair samples. This highly automated procedure utilizes SPDE for pre-concentration and
on-coating derivatization as well as GC and triple quadrupole MS/MS for selective and sensitive
detection. All these steps, apart from washing and cutting of the hair samples, are performed without
manual intervention on a robot-like autosampler.
SPDE is a solventless extraction technique related to solid-phase microextraction (SPME). The
analytes are absorbed from the sample headspace directly into a hollow needle with an internal
coating of polydimethylsiloxane by repeated aspirate/dispense cycles.
The HS-SPDE/GC/MS/MS procedure was applied to the analysis of methadone, the trimethylsilyl
derivatives of cannabinoids and the trifluoroacetyl derivatives of amphetamines and designer
drugs. The method was shown to be sensitive with detection limits between 6 and 52 pg/mg hair
matrix and precision between 0.4 and 7.8% by the use of an internal standard technique. Linearity
was obtained from 0.120 ng/mg with coefficients of correlation between 0.995 and 0.999.
Compared with conventional methods of hair analysis, HS-SPDE/GC/MS/MS is easier to use,
substantially faster, with the degree of sensitivity and reproducibility demanded in clinical and
forensic toxicology. The main advantage of the SPDE technique in relation to SPME is the robustness
of the capillary. Copyright # 2003 John Wiley & Sons, Ltd. 瑞士CTC多功能进样器 Combi-PAL 液体/顶空/固相微萃取/ITEX
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