在进行合成化合物的生物活性筛选之前,支持化学制药的药物学家和分析科学家通常会 评定它们的纯度。本文采用通用方法结合多检测器系统,对 30 个库化合物进行了快速、 自动化的纯度评定。Agilent 6130 系列单四极杆 LC/MS 系统与紫外 (UV) 和蒸发光散 射检测器 (ELSD) 联用,可以检测到单独采用一种检测模式可能丢失的杂质峰。安捷伦 Analytical Studio Reviewer 软件为化合物的确证和纯度的评定提供了更简洁的用户数 据处理界面。
Waters ACQUITY QDa质谱检测器是一款创新型质谱检测器将其整合到现有的液相色谱配置中,可用于补
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