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人睾丸间质细胞HLC
- 品牌:美国ScienCell
- 货号: 4510
- CAS编号:
- 产地:美国
- 供应商报价: 面议
- 上海科学仪器有限公司 更新时间:2024-02-18 17:34:48
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- 详细介绍
Leydig Cells (LC) are located in the interstitium of the testis near the seminiferous tubules. One of the main functions of LC is to produce testosterone after stimulation by pituitary luteinizing hormone. LC, through synthesis of testosterone, play a key role in mammalian sex determination by inducing differentiation of the Wolffian ducts into male reproductive organs. Additionally, LC produce insulin-like growth factor 3 which is required for scrotal descent of the testis. Recent studies have indicated that molecules such as cyclic nucleotide phosphodiesterases can modulate testosterone production in LC, suggesting that testosterone synthesis may be manipulated using pharmacological targeting. Cultured Human LC are a useful in vitro model to better understand testicular development and to develop treatments for male reproductive disorders.