人直肠微血管内皮细胞HRecMEC

The human rectum is located in the lower gastrointestinal tract and functions as a temporary storage site for fecal material. Endothelial cells in the rectum line the interior surface of the blood vessels and form the interface between intravascular and extravascular compartments. Endothelial cells limit the passage of cellular and soluble substances between the blood vessels and the tissues. Endothelial cells also play critical roles in angiogenesis, vasculogenesis, and the inflammatory response. Rectal microvascular endothelial cells (RecMEC) have been implicated as a major contributing factor to the progression of rectal cancer. Human RecMEC (HRecMEC) are a useful in vitro model to elucidate the mechanisms of angiogenesis and to develop treatments for rectal cancer.