人口腔角质细胞HOK

Oral keratinocytes act as the major barrier to physical, microbial, and chemical agents that may cause local cell injury. They are involved in the proinflammatory process through the production of cytokines either constitutively or after a variety of stimuli [1]. Consequently, oral keratinocytes may potentially participate in control领 oral infections through an inflammatory process involving different interleukins, such as IL-1β and IL-18 [2]. Oral keratinocytes express a variety of differentiation markers, the expression of which is influenced by calcium-induced changes in the transcription of target genes [3]. Oral keratinocytes share major structural and functional features with the well-characterized dermal keratinocyte and are a good model to study basic keratinocyte biology, as well as, processes of immortalization and malignant transformation.