人脑血管外膜成纤维细胞HBVAF

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. Fibroblasts in the vascular adventitia, the outermost connective tissue covering of a vessel, have been implicated in vascular injuries through transient changes in their phenotypic and proliferative properties, and accumulation of extracellular matrix proteins in the adventitia. Such changes play an important role in the remode领 of vessel walls under pathological conditions, and thus suggest great potential for site-specific vascular wall gene therapy to regulate vascular tone through vascular adventitial fibroblasts.