人膀胱成纤维细胞HBdSF

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Their durability also makes them amenable to a wide variety of manipulations ranging from studies employing gene transfection to microinjection. There is evidence that fibroblasts in various parts of the body are intrinsically different [1]. Fibroblasts within tissues are exposed to a dynamic mechanical environment, which influences the structure integrity of both healthy and hea领 soft tissue. Fibroblasts secrete a non-rigid extracellular matrix that is rich in type I and/or type III collagen [2]. Human bladder stromal fibroblasts (HBdSF) also secrete FGF-7, which interact primarily with bladder epithelial cells [3]. FGF-7 secreted by HBdSF is essential for stimulating the formation of a multilayered stratified bladder epithelium [4].