Anti-HLA-B27 (EP-4)
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Anti-HLA-B27(EP-4)CatalogNumber:DZ77217Quantitysize:0.1ml(dilutewithpH7.40.01MPBSorantibodydiluent)Background:Majorhistocompatibilitycomplex(MHC)moleculesformanintegralpartoftheimmuneresponsesystem.Theyarecell-surfacereceptorsthatbindpep-tidesandpresentthemtoTlymphocytes.Humanleukocyteantigens(HLAs)arepolymorphicmembersoftheMHCfamilythatarespecificallyinvolvedinthepresentationofantigenstotheTcellreceptor.TherearetwoclassesofHLAantigens:classI(HLA-A,HLA-BandHLA-C)andclassII(HLA-D).ClassImoleculesareexpressedinnearlyallcellsandplayacentralroleintheimmunesystembypresentingpeptidesderivedfromtheendoplasmicreticu-lum.ThedifferentialstructuralpropertiesofMHCclassIandclassIImole-culesaccountfortheirrespectiverolesinactivatingdifferentpopulationsofTlymphocytes.HLA-Bencodesamembraneanchoredheavychainwhichhetero-dimerizeswithalightchain.Specificity:Anti-HLA-B27(EP-4)anti-HLA-B27isamousepolyclonalantibodyunconjugatedspecificforHLA-B27antibodyofhumanepitopemappingneartheaminoterminusofHLA-B27antigenofhumanuseforwesternblotting,elisa,immunoprecipitationandimmunohistochemistryProteinAaffinitychromatographypurification,purity:>95%Isotype:IgMmolwt:38kDaApplication:Westernblotting1:100-500Immunohistochemistry1:100-500ELISA1:500-1000Optimalworkingdilutionsmustbedeterminedbytheenduser.Storage:Anti-HLA-B27(EP-4)Storeat-20℃foroneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃.ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.
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