Dynamite8

The Dynamite8 is a fully automated dynamic clamp add-on integrating seamlessly into an 8-channel or 4-channel Patchliner. IK1 simulation and seal compensation are individually calculated for each cell, for up to 8 cells simultaneously. Applying our dynamic clamp method results in stable, negative resting membrane potentials and improved stability and shape of APs recorded from human induces pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs).

Stable and reliable AP recordings allow for the acquisition of full, cumulative dose-response curves, providing the basis for automated AP pharmacology recordings for cardiac safety and drug testing. No user intervention is required during experiments: all parameters are calculated and applied by the Dynamite8. If desired, all critical parameters are easily accessible for modification through the user.