-
公司新闻
-
P2X3在慢性咳嗽中的作用
发布:耐尼恩技术(北京)有限公司浏览次数:506P2X受体是由细胞外ATP激活的三聚体配体门控离子通道。当被激活时,小的一价阳离子通过孔。P2X通道已被证明在炎症、内脏和神经病理性疼痛状态中起作用,此外,在气道高反应性、偏头痛、瘙痒和癌痛中也起作用。最近,P2X2/3和P2X3受体拮抗剂MK-7264(gefapixant)已进入难治性和原因不明的慢性咳嗽的III期临床试验。
Key Publications:
Ford, A.P. & Undem, B.J. 2013. The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Frontiers in Cellular Neuroscience
Ford, A.P. 2012. In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic SignallingMeasuring P2X3 Channels
P2X3 Channels can be measured using automated patch clamp when expressed in cell lines, or using the Orbit instruments when they are recombinantly expressed in bilayers.
High throughput automated patch clamp
Parallel bilayer recordings
Cytotoxicity measurements
Application Notes:
P2X3 - "Activation and inhibition of P2X3 channels recorded on the Patchliner"
Publications using Instruments from Nanion
2019 - Action of MK‐7264 (Gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation
2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening
2021-09-14 -
免责声明
①本网刊载上述内容,并不代表本网赞同其观点或证实其内容的真实性,不承担此类作品侵权行为的直接责任及连带责任
②若本站内容侵犯到您的合法权益,请及时告诉,我们马上修改或删除。邮箱:hezou_yiqi
-
认证会员 第 5 年
耐尼恩技术(北京)有限公司
认证:工商信息已核实
- 产品分类
- 品牌分类
-
仪企号耐尼恩技术(北京)有限公司
-
友情链接
-
手机版开启全新的世界m.yiqi.com/zt72470/