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90plus 纳米粒度仪应用案例-31

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【导读】90plus纳米粒度仪应用案例文献名:Compositeglycidylmethacrylateddextran(Dex-GMA)/gelatinnanoparticlesforl...

90plus纳米粒度仪应用案例

文献名:Compositeglycidylmethacrylateddextran(Dex-GMA)/gelatinnanoparticlesforlocalizedproteindelivery

作者:Fa-mingChen,Zhi-weiMa,Guang-yingDongandZhi-fenWu

DepartmentofPeriodontologyandOralMedicine,SchoolofStomatology,FourthMilitaryMedicalUniversity,Xi'an710032,China

DepartmentofPhysiologyandDevelopmentalBiology,Provo,UT,USA

摘要:

Aim:Localizeddeliveryofgrowthfactorshassignificantpotentialasafuturetherapeuticstrategyintissueengineeringandregenerativemedicine.Ananoparticlevehiclewascreatedandevaluatedinthisstudywiththeintenttodelivergrowthfactorsforperiodontalregeneration.

Methods:Novelcompositenanoparticlesbasedonglycidylmethacrylatederivatizeddextrans(Dex-GMA)andgelatinwerefabricatedbyafacilemethodwithoutusinganyorganicsolvents.Theconfigurationsoftheresultantnanoparticleswereevaluatedbytransmissionelectronmicroscopy,scanningelectronmicroscopy,andatomicforcemicroscope.Theirsurfaceswerecharacterizedbyzeta-potentialmeasurements,afterwhichtheirpropertiesincludingswel领,degradation,drugrelease,andcytotoxicitywerealsoinvestigatedusinginvitromodels.

Results:TheparticlesizeofDex-GMA/gelatinnanoparticles(DG-NPs)rangedfrom20to100nmandshowedamono-dispersesizedistribution(meandiameter53.7nm)andastronglynegativesurfacezetapotential(20mV).TheDG-NPswerecharacterizedbygoodswel领anddegradationpropertiesinmediaincludingdextranase.Theinvitrodrugreleasestudiesshowedthattheefficientbonemorphogeneticprotein(BMP)releasefromDG-NPswasmaintainedformorethan12dunderdegradationconditions,wheremorethan90%oftheloadedBMPwasreleased.NoanyrelevantcelldamagecausedbyDG-NPswasfoundinthecytotoxicitytestsforaperiodof24h.

Conclusion:ThesecombinedresultsdemonstratethatDG-NPsfulfillthebasicprerequisitesforgrowthfactordelivery.Withfurtherinvivostudies,thosenanoparticlesmayofferapromisingvehicleforthedeliveryofactivedrugstotheperiodontium.

关键词:drugdeliverysystems,drugcarriers,bonemorphogeneticprotein,periodontalregeneration,growthfactors


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2004-11-02 09:23:03
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