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Rabbit Anti-IGF1R/CD61抗体说明书

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【导读】RabbitAnti-IGF1R/CD61抗体说明书 RabbitAnti-IGF1R/CD61抗体说明书Cat.Number: RS-0342RQuantitysize:...

RabbitAnti-IGF1R/CD61抗体说明书

RabbitAnti-IGF1R/CD61抗体说明书

Cat.Number: RS-0342R

Quantitysize: 0.1ml (dilutewithpH7.4   0.01MPBSordiluentofantibody)

Background:Thisreceptorbindsinsulin-likegrowthfactor1(IGF1)withahighaffinityandIGF2withaloweraffinity.Ithasatyrosine-proteinkinaseactivity,whichisnecessaryfortheactivationoftheIGF1-stimulateddownstreamsigna领cascade.WhenpresentinahybridreceptorwithINSR,bindsIGF1.PubMed:12138094showsthathybridreceptorscomposedofIGF1RandINSRisoformLongareactivatedwithahighaffinitybyIGF1,withlowaffinitybyIGF2andnotsignificantlyactivatedbyinsulin,andthathybridreceptorscomposedofIGF1RandINSRisoformShortareactivatedbyIGF1,IGF2andinsulin.Incontrast,PubMed:16831875showsthathybridreceptorscomposedofIGF1RandINSRisoformLongandhybridreceptorscomposedofIGF1RandINSRisoformShorthavesimilarbindingcharacteristics,bothbindIGF1andhavealowaffinityforinsulin.

Specificity:     ·anti-CD61isarabbitmonoclonalantibodyunconjugated

               ·specificforCD61of  ratandmo 

               ·epitopemappingneartheaminoterminusofCD61of  

                  hu,ratandmoorigin

               ·useforwesternblotting,elisa,immunoprecipitation    

                  andimmunohistochemistry

· ProteinAaffinitychromatographypurification,purity:>95%

·Isotype:IgG

·molwt:82kDa

Application:    ·Westernblotting:1:100-500

·Immunohistochemistry:1:100-500

·ELISA:1:500-1000

· Optimalworkingdilutionsmustbedeterminedbytheenduser.

Storage:  Storeat–20ºCforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20ºC.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4ºC.

ImportantNote: Thisproductassuppliedis intendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.

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2004-07-13 09:31:27
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