Injectable hydrogels with in situ-forming hydrophobic domains: oligo(D,L-lactide) modified poly(olig

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• Injectable hydrogels with in situ-forming hydrophobic domains: oligo(D,L-lactide) modified poly(olig

  Injectable,insitu-gel领nanostructuredhydrogelshavebeenpreparedfromhydrazideandaldehydefunctionalizedpolymerprecursorsbasedonacopolymerofoligo(ethyleneglycol)methacrylate(OEGMA)andanoligo(lacticacid)macromonomer(OLA)withvaryinglacticacidchainlengths.Theresultinghydrogelscontainamixofchemical(hydrazonebondformationbetweenhydrazideandaldehydegroups)andphysical(hydrophobicinteractionsbetweenOLAchains)cross-linkswhichformcompetitivelyasafunctionoftheOLAchainlengthanddensity.AnincreaseintheOLAchainlengthanddensityresultsintheformationofmorephysicalcross-linksandfewerchemicalcross-links.Tuningtherelativeprevalenceofphysicalandchemicalcross-linkformationfacilitatedlargelyindependenttuningofgelmechanicsrelativetogelswel领anddegradation.Small-angleneutronscatteringoftheseOLA-containinghydrogelsrevealsamicrostructureconsistingofassociativehydrophobicdomains,basedonanincreasedscatteringintensityanddecreasedblobsizerelativetothatobservedforPOEGMAhydrogelspreparedwithouttheOLAco-monomer.ThepresenceofhydrophobicOLAdomainsincreasestheuptakeandslowsthereleaseofbovineserumalbumin,aproteinwell-knowntoassociatewithhydrophobicdomains.Coupledwiththeobservedcytocompatibilityofthereactiveprecursorpolymersusedtopreparethehydrogels,weanticipatesignificantpotentialapplicationsofthesehydrogelsfortheprolongedreleaseofhydrophobiccargoes.[详细]

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