Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

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2018-08-31 10:11 302阅读次数

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• Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

  Exosomesarenaturallyoccurringbiologicalnanovesiclesutilizedbytumorstocommunicatesignalstolocalandremotecellsandtissues.Melanomaexosomescaninciteaproangiogenicsigna领programcapableofremode领tissuematrices.Inthisstudy,weshowexosome-mediatedconditioningoflymphnodesanddefinemicroanatomicresponsesthatlicensemetastasisofmelanomacells.Homingofmelanomaexosomestosentinellymphnodesimposessynchronizedmolecularsignalsthateffectmelanomacellrecruitment,extracellularmatrixdeposition,andvascularproliferationinthelymphnodes.Ourfindingshighlightthepathophysiologicroleandmechanismsofanexosome-mediatedprocessofmicroanatomicnichepreparationthatfacilitateslymphaticmetastasisbycancercells.[详细]

  2018-08-31 10:11

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