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Recombinant Human TNFR2/CD120b/TNFRSF1B(His Tag)

品牌：翌圣生物
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供应商报价：面议

翌圣生物科技(上海)股份有限公司更新时间：2024-12-24 09:03:45

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产品信息

产品名称	产品编号	规格
Recombinant Human TNFR2 / CD120b / TNFRSF1B (His Tag)	93752ES25	25 μg
	93752ES60	100 μg
	93752ES76	500 μg
	93752ES80	1 mg

产品描述

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa. Human TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors. Polymorphisms of the human TNFR2 gene, which result in increased expression of both membrane-bound and soluble TNF RII, have been associated with several autoimmune diseases including Crohn’s disease, systemic lupus erythematosus, and familial rheumatoid arthritis.

产品性质

别名（Synonyms）	CD120b, Etanercept, p75TBPII, p75TNFR, TNF RII, TNF-R2, TNF-R75, TNFR80, TNFRSF1B, TNFR2, TBPII, TNFBR, TNFR1B
Uniprot No.	P20333-1
表达区间及表达系统（Source）	Recombinant Human TNFR2 / CD120b / TNFRSF1B Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu23-Asp257.
分子量(Molecular Weight)	Approximately 26.2 kDa. Due to glycosylation, the protein migrates to 48-60 kDa based on Tris-Bis PAGE result.
外观(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
纯度（Purity）	> 95% as determined by SDS-PAGE > 90% as determined by HPLC
活性（Activity）	ELISA Data: Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Biotinylated Human TNF alpha, His Tag with the EC₅₀ of 16.6 ng/mL determined by ELISA. ELISA Data: Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC₅₀ of 12.7 ng/mL determined by ELISA.
内毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制剂（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.

运输与保存方法

冰袋运输。-20℃至-80℃保存，一年有效期。

复溶后，-20 至 -80°C，在未开封状态下保存 3-6 个月。复溶后，2-8°C 保存 2-7 天。

建议第一次使用时分装冻存，避免反复冻融。

注意事项

避免反复冻融。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
本产品仅作科研用途！

产品数据

Tris-Bis PAGE

Human TNFR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human TNFR2 is greater than 90% as determined by SEC-HPLC.

ELISA Data

Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Biotinylated Human TNF alpha, His Tag with the EC₅₀ of 16.6 ng/mL determined by ELISA.

ELISA Data

Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC₅₀ of 12.7 ng/mL determined by ELISA.

HB220707

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