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Keywords:Epoxides;Amines;2-Aminoalcohols;Yttriumnitratehexahydrate;RegioselectivityAminoalcoholsconstituteanimportantclassofcompoundshavingbothchemicalandbiologicalapplic... Keywords:
Epoxides; Amines; 2-Amino alcohols; Yttrium nitrate hexahydrate; Regioselectivity Amino alcohols constitute an important class of
compoundshaving both chemical and biological applications. They are important pharmacophores present in various inhibitors and are used
as building blocks for the synthesis of biologically active natural products， insecticidal agents and chiral auxillaries for asymmetric
reactions.1a–f They act as starting materials for the synthesis of oxazolines which are useful in the polymer industry.1g Owing to their
widespread applications， the synthesis of amino alcohols has received much attention in recent years.
Traditionally， 2-amino alcohols are prepared by heating an epoxide with an excess of amine at elevated temperature.
The use of a high temperature leads to undesired side reactions and also limits the applicability towards temperature
sensitive substrates. To overcome these drawbacks various promoters such as ZnCl2，2 ScOTf，3 MgBr2OEt2，4 67 9
bismuth salts，5 CoCl2， CuBF4， DIPAT，8 Ti(OiPr)4， 1011 12TaCl5， ZrCl4， Sm(OTf)3， potassium dodecatungstocobaltate，
13 and aluminosilicate14 have been employed for the above transformation. The use of non-conventional techniques
such as microwave irradiation at elevated temperaturehas also been reported.15 Recently， the use of Al(OTf)3 (1 mol %)
as catalyst in toluene at reflux has also been reported.16 Although significant advances have been made
in this area， low regioselectivity， longer reaction time， use of elevated temperature， high catalyst loading， toxic solvents
and lower substrate compatibilitylimit their applications.Thus there is a need to develop an efficient catalytic
protocol for ring opening of various epoxides with aliphatic， aromatic andheteroaromatic amines under ambient conditions