Amphetamines are controlled substances which
are potent stimulants that induce fee领s of
strength and energy while decreasing the need to
sleep or eat. The majority of illegal amphetamine
products are racemic; consequently, both isomers
will appear in the biological fluids unchanged. In
comparison the break-down products formed by
the metabolism of most pharmaceutical drugs
show the appearance of pure amphetamine
enantiomers. Circular dichroism is a form of light
absorption spectroscopy that measures the
difference in absorbance of right- and leftcircularly
polarized light (rather than the commonly
used absorbance of isotropic light) by a substance.
Since different enantiomers absorb different
portions of the light, it provides and excellent
means for enantiomer detection. In this
application CD will be used to study the isomers of
amphetamine and methamphetamine.
Introduction
Amphetamines are synthetic drugs that stimulate the JASCO圆二色光谱仪CD J-1500
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