Capillary zone electrophoretic chiral discrimination

内容节点: 概述; 实验/设备条件; 样品提取; 实验/操作方法; 实验结果/结论; 仪器/耗材清单

A charged highly water-soluble CD derivative, 6-O-(2-hydroxy-3-trimethylammoniopropyl)- -CD (herein noted as 6-HPTMA- -CD) was synthesized and successfully used as a chiral selector for enantiomeric separation of some acidic compounds by CZE in an uncoated capillary. Substitution with 2-hydroxy-3-trimethylammoniopropyl groups at the primary hydroxyl group of the CD was aimed at influencing the magnitude and selectivity of analyte-CD interactions. The behavior of 6-HPTMA- -CD was compared with that of the commercially available quaternary ammonium- -CD (QA- -CD) under the same separating conditions. The experiments were carried out using a BGE consisting of 50 mM phosphate in the pH range of 4-6 by adding a relatively low concentration of chiral selector (less than 10 mM). The effects of the concentration of CD and the pH of the electrolyte on the resolution of these compounds were studied. GX毛细管电泳仪(紫外检测)CL1030

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