Recombinant monoclonal antibodies (mAbs) have emerged as important therapeutic agents for the treatment of different diseases. This technology has been extended by the development of antibody drug conjugates (ADCs).
Recombinant monoclonal antibodies (mAbs) have emerged as important therapeutic agents for the treatment of different diseases. This technology has been extended by the development of antibody drug conjugates (ADCs). [详细]
The ion microprobe or secondary ion mass spectrometer(SIMS) has existed for almost fifty years ， but althoughgreat improvements have been made in sensitivity and easeof use, the lateral resolution has not improved quite as much.Early papers reported measurements from fifty micron areas
[详细]
This Application Note demonstrates the utility of capillary electrophoresis/mass spectrometry (CE/MS) for the analysis of intact monoclonal antibodies (mAbs). The Agilent 7100 CE System coupled to an Agilent 6530 Q-TOF LC/MS was used to study the intact and reduced forms of mAbs. The combination of mass measurements obtained by CE/MS and the data processing capabilities of Agilent MassHunter and BioConfi rm Software enables the identifi cation of heterogeneity in an intact mAb and its fragments. The result demonstrates the utility of CE/MS as a complementary technique to liquid chromatography/mass spectrometry (LC/MS) for the analysis of mAbs.[详细]
Diatoms are worldwide abundant unicellular microalgae (Fig.1). Their fossilized remains are the main component of diatomite, a mineral widely utilized in many differentindustries as an absorbent or additive. The chemical composition of the shells is critical for the properties of the final product. Therefore, there is a huge need to analyze the elemental distribution in the original diatoms. [详细]
The development of a Time of Flight Secondary Ion Mass Spectrometer (TOF-SIMS) that can be
attached to a FIB-SEM instrument provides an analyzer that very well complements the standard EDS detector. However, contrary to EDS, it gives much better depth resolution, possibility of depth profiling as well as distinguishing isotopes. [详细]
Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry
在线留言
沪公网安备 31011502008050号
参与评论
登录后参与评论