【Fail fast, fail early】美国Pion年度PAMPA/FLUX用户会议通知

2016年4月11日-12日，美国Pion年度PAMPA/FLUX用户会议将在Pion美国总部马塞诸塞州的比尔里卡举办。届时，来自的制药企业将共聚一堂，体验并分享PAMPA/FLUX为药物研究带来的前所未有的GX率。

本次会议是一年一度的PAMPA/FLUX用户会议，本期在美国Pion总部马塞诸塞州的比尔里卡举办，上海凯来作为美国Pion全线产品ZG区总代理应邀参会并参加培训。随着ZG制药市场的发展，ZG医药公司比过去任何时候都更加专注于创新和研发，明年的PAMPA/FLUX用户会议有望在ZG上海举办。

什么是PAMPA?

What is PAMPA

PAMPA是药物通透性测试系统

准确，GX，可靠

PAMPA你能做什么？

What can you do

拥有PAMPA，您可以

测量并绘制pH-通透性曲线

控制未搅动水层(UWL)

测量膜通透性Pm

测量固有通透性Po

Double-SinkTM ZL技术的PAMPA

快速、高度重复

低成本

易于比较有效通透性Pe的区别

提供更宽的pH测试范围

结果可靠、人为影响因素小

用过PAMPA请举手？

Any user?

我们的用户不仅仅是......

PAMPA/FLUX

给您的通透性测试带来前所未有的GX率

【Fail fast, fail early】

Annual U.S. PAMPA/FLUX Training Course

April 11, 2016 - April 12, 2016

Pion Inc., 10 Cook Street, Billerica MA 01821

Agenda 会议日程

Monday, April 11th

9:00 12:00 (with coffee break), Konstantin Tsinman, CSO (Pion Inc.)

口General background of membrane permeability: partitioning, diffusion and permeability equations.

口Practical aspects of permeability determination in cell-based and artificial membranes. Why we do not

measure membrane permeability in most cases.

口Differences between PAMPA membranes. Using Double-Sink? PAMPA results in simple models and

for prediction of passive transport in vivo.

12:00 1:00 Lunch (provided)

1:00 2:30 Jankiben Patel, Lab Chemist (Pion Inc.)

口Lab demonstration of PAMPA Assay: robotic versus manual (if requested).

2:30 5:00 (with a break), Oksana Tsinman, Senior Research Scientist (Pion Inc.)

口Proper planning of PAMPA experiment: from one condition to everything into choosing the best

conditions prior to the experiments. Usage of prediction software to choose the assay conditions. Show

examples, when ahead planning helps in obtaining best quality data. Interactive practice.

5:00 6:20 Konstantin Tsinman

口Blood brain barrier penetration prediction with BBB PAMPA.

口Using PAMPA for formulation screening.

6:20 7:30 All Social hour

Tuesday, April 12th

9:00 9:45 User Presentation of Case Study

TBD

10:00 12:00 Balint Sinko, Manager PAMPA Global Support (Pion Inc.)

口Development of Skin PAMPA for Fast Prediction of Skin Penetration. Practical aspects of using the

model for solutions, creams and patches. Lab demonstration of Skin PAMPA applications.

12:00 1:00 Lunch (provided)

Tuesday, April 12 (continued)

1:00 1:45 Haotian Wang, Product Support Manager (Pion Inc.), Ram Lingamaneni, Lab Chemist (Pion Inc.)

口Extending use of PAMPA to the later stage drug development. Lab demo of μFLUX apparatus.

2:00 4:30 Konstantin Tsinman, Balint Sinko

口Analysis of different data sets. How to recognize bad data and to recover decent results even from

imperfect data sets. Highlighting the software features (saving blanks, updating excel files based on

individual refinement, saving averaged results in the Excel, etc.)

口Interactive analysis of the data sets. Discussion on the strategy how to get best results. Calculation of

intrinsic permeability data. Calculation of membrane permeability in the pH regions overshadowed by

unstirred water layer. Calculation of Flux for formulation assays.

4:30 5:00 All Questions/answers, round table discussions and more lab practice if needed.

上海凯来为美国Pion全线产品ZG区总代理

关于美国Pion

Pion位于美国马塞诸塞州的比尔里卡，是一家专业从事药物研究设备开发的公司。Pion公司的核心业务是测定药物的溶解度、溶出度、通透性以及人体吸收。我们通过仪器、软件和实验设备来筛选和分析药物。Pion的开发者都是药物研究的ZS科学家，参与多本药物吸收和代谢经典教材的编制，超过1000篇专业文献使用了我们的产品，用户遍布。

关于凯来

上海凯来实验设备有限公司成立于2004年，主要经营进口实验室仪器，总部位于上海张江高科，目前在北京，广州，成都，杭州，南京，青岛等地设有办事处。

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