Anti-Snail 1抗体

RabbitAnti-Snail1antibody

CatalogNumber:RS-01371R

Quantitysize:0.1ml(dilutewithpH7.40.01MPBSorantibodydiluent)Background:Thezincfingertranscriptionfactor'SNAIL'wasfirstidentifiedinDrosophilaand,alongwith'twist',abasichelix-loop-helixtranscriptionfactor,isindispensableformesodermformation.SNAILisarepressorofmouseE-cadherintranscription,withexpressionofSNAILinverselycorrelatedwithexpressionofE-cadherin.AbnormalexpressionofSNAILcouldunderliethetumorigenicconversionofepitheliaassociatedwithlossofE-cadherinexpressionthroughscreeningmouseandhumancelllinesandbyinsituhybridizationofprimaryhumantumorsundergoingmalignantprogression.

Function:

Involvedintheepithelialtomesenchymaltransition(EMT)andformationandmaintenanceofembryonicmesoderm.Bindsto3E-boxesoftheE-cadheringenepromoterandrepressesitstranscription.

Specificity:Anti-Snail1isarabbitpolyclonalantibody

specificforSnail1ofhuman,rat,mouse

useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry

ProteinGaffinitychromatographypurification,purity:>95%

Isotype:IgG

molwt：29kDa

Application:

WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500

notyettestedinotherapplications.
optimaldilutions/concentrations首ldbedeterminedbytheenduser..

Storage:Storeat-20℃foroneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃

ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.