Paclitaxel产品信息

产品名称：Paclitaxel

化学名：N-BENZYL-BETA-PHENYLISOSERINEESTER

CASNo：33069-62-4

分子式：C47H51NO14

分子量：853.92

纯度：99%

溶解度：Solubleto25mMinethanolandto100mMinDMSOwithgentlewarming

保存：2-8°C

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货号：abs810020

规格：大包装询价

库存：现货

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生物活性：

Antitumoragent;promotesandstabilizestubulinpolymerization,causingcellcyclearrest.Inducesautocatalyticactivationofcaspase-10inCCRF-HSB-2cells,triggeringapoptosis.

Itselectivelyinhibitstheproliferationofhumanendothelialcells(ECs)atultralowconcentrations(0.1-100pM),whileitinhibitsnon-endothelialtypehumancellsat10(4)-to10(5)-foldhigherconcentrations,withIC50=1-10nM.Theselectivityofpaclitaxelinhibitionofcellproliferationisalsospeciesspecific,asmouseECsarenotsensitivetopaclitaxelatultralowconcentrations.TheyareinhibitedbyhigherconcentrationsofpaclitaxelwithIC50=1-10nM.InhibitionofhumanECsbypaclitaxelatultralowconcentrationsdoesnotaffectthecellularmicrotubulestructure.PaclitaxelblockscellsinG2-M,andthismayresultinaschedule-dependenteffectonpaclitaxelcytotoxicity.

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