分享 收藏

Recombinant Human MIC-B Protein

品牌：翌圣生物
产地：
供应商报价：面议

翌圣生物科技(上海)股份有限公司更新时间：2025-01-10 08:26:24

销售范围售全国

入驻年限第2年

营业执照已审核

同类产品其他蛋白(482件)

立即扫码咨询

联系方式：400-611-1883

联系我们时请说明在仪器网（www.yiqi.com）上看到的!

扫码分享

为您推荐

详细介绍

MIC-B (MHC class I chain-related gene B) is a single-pass type I member protein. A closely related protein, MICA, shares 85% amino acid identity with MICB. It is widely expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In addition to this, it is produced by hepatocellular carcinomas, which is only in tumor cells but not in surrounding non-cancerous tissue and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.

Product Properties

Synonyms	MHC class I chain-related protein B, MICB, stress inducible class I homolog
Accession	NP_005922
GeneID	4277
Source	E.coli-derived human MIC-B protein, Ala23-Asp309.
Molecular Weight	Approximately 32.8 kDa.
AA Sequence	AEPHSLRYNL MVLSQDESVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AEDVLGAKTW DTETEDLTEN GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH EDSSTRGSRH FYYDGELFLS QNLETQESTV PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR RTVPPMVNVT CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG TYQTWVATRI RQGEEQRFTC YMEHSGNHGT HPVPSGKVLV LQSQRTD
Tag	None
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>95% by SDS-PAGE and HPLC analyses.
Biological Activity	The specific activity is determined by binding MICB antibody in ELISA. Fully biologically active when compared to standard.
Endotoxin	< 1.0 EU per 1μg of the protein by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 150 mM NaCl, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.