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Recombinant Human P53 R175H(HLA-A*02:01)(His-Avi Tag)

品牌：翌圣生物
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翌圣生物科技(上海)股份有限公司更新时间：2024-12-24 09:03:45

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详细介绍

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

产品性质

别名（Synonyms）	MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53
Uniprot No.	A0A140T913(HLA-A*02:01)&P61769(B2M)& HMTEVVRHC
表达区间及表达系统（Source）	Recombinant Human P53 R175H (HLA-A02:01) Complex Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Gly25-Thr305 (HLA-A02:01),Ile21-Met119(B2M) and HMTEVVRHC peptide.
分子量(Molecular Weight)	The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.
外观(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
纯度（Purity）	> 95% as determined by SDS-PAGE and HPLC
内毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制剂（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
复溶（Reconstitution）	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.