Biotinylated Human Nectin-4 Protein IgV Domain, His-Avi Tag

Nectin-4, also known as PVRL4 is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. The extracellular domain of human Nectin-4 shares 91%, 92%, 93%, 91% and 90% amino acid sequence homology with the corresponding regions of mouse, rat, canine, porcine and bovine Nectin-4, respectively. In many human ductal breast or non-small cell lung carcinomas, Nectin4 is upregulated. In forming adherens junctions, trans interactions of Nectin-4 initiate cell-cell interactions and recruit intracellular cadherins through afadin and other junctional proteins. These interactions organize the actin cytoskeleton, strengthen attachment to basement membrane and promote further cell-cell connections.

产品性质

运输与保存方法

The products are shipped with ice pack and can be stored at -80°C for 1 year.

Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.

注意事项

1.For your safety and health, please wear lab coats and disposable gloves for operation.

2.For research use only!