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Recombinant Human NKG2D/CD314(His-Avi Tag)

品牌：翌圣生物
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供应商报价：面议

翌圣生物科技(上海)股份有限公司更新时间：2025-03-03 09:43:21

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详细介绍

NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. Human NKG2D is expressed on CD8+ alpha beta T cells, gamma δ T cells, NK cells and NKT cells. In mouse systems NKG2D also occurs on macrophages. Human ligands for NKG2D include MICA, MICB, and ULBP1, 2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection.

产品性质

别名（Synonyms）	CD314, D12S2489E, KLR, NKG2-D, NKG2D
Uniprot No.	P26718
表达区间及表达系统（Source）	Recombinant Human NKG2D / CD314 Protein is expressed from HEK293 Cells with His tag and Avi tag at the N-terminal. It contains Phe78-Val216.
分子量(Molecular Weight)	Approximately 19 kDa. Due to glycosylation, the protein migrates to 36-38 kDa based on Tris-Bis PAGE result.
外观(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
纯度（Purity）	> 95% as determined by SDS-PAGE
活性（Activity）	ELISA Data: Immobilized Human NKG2D, His Tag at 1 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-NKG2D Antibody, hFc Tag with the EC₅₀ of 4.7 ng/mL determined by ELISA.
内毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制剂（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
复溶（Reconstitution）	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL` is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.