The measurement of lipids in a biological
matrix to
study
their responses to
diseases, drugs, genetic modifications,
and other stimuli requires a Q
-
TOF
system with outstanding resolution,
mass accuracy, and sensitivity.
In this application, the 6545 Q
-
TOF
and 1290 Infinity LC system are used
to analyze an induced sputum lipid extract
from a
donor
with chronic obstructive
pulmonary disease (COPD). T
he 6545
Q
-
TOF is tuned by novel Swarm Autotune
for optimal performance in the m/z range
of the lipids, and data acquired in both
positive and negative ionization modes
with reference mass correction Agilent 6545 四极杆飞行时间液质联用系统
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