通过Biotage Isolera快速纯化液相制备色谱帮助合成小分

A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 receptors. As predicted from the previously established species specificity, these peptidomimetics were found to be devoid of MrgX1 agonist activity. In contrast, these compounds acted as agonists of MrgC and/or MrgC11 with varying degrees of potency. These new peptidomimetics 首ld complement the existing small molecule human MrgX1 agonists and enhance our ability to assess the therapeutic utility of targeting Mrg receptors in rodent models. Biotage 快速纯化制备液相色谱 Flash Isolera one Biotage 快速纯化制备液相色谱 Flash Isolera Prime Biotage 快速纯化制备液相色谱 Flash Isolera LS