通过Biotage Isolera快速纯化液相制备色谱帮助进行铑催

We report herein a method that allows for the formation of a CeN bond between the Ce3 carbon of alactams and the nitrogen atom of indoles. A general procedure for the coup领 of indoles and a-lactams in only 25 min with high yield is reported. The scope of the reactionwas extended by the development of a method for the in situ generation of less stable phenyl-substituted a-lactams. The developed method provides an atom-economical method for the formation of substituted a-amino amides that are found in a variety of biologically-active compounds. Biotage 快速纯化制备液相色谱 Flash Isolera one Biotage 快速纯化制备液相色谱 Flash Isolera Prime Biotage 快速纯化制备液相色谱 Flash Isolera LS