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仪器网/ 行业应用/ 解决方案/ 通过Biotage微波合成仪黄嘌呤氧化酶YZ活性的研究以及

通过Biotage微波合成仪黄嘌呤氧化酶YZ活性的研究以及

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Some 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are presented. The compounds 6g, 6h and 6e were found to be significantly active against XO. The compound 6g emerged as the most potent XO inhibitor as compared to allopurinol and free radical scavenger. The molecular docking of 6g into the XO active site highlighted its mode of binding and important interactions such as hydrogen bonding, pp stacking with amino acid residues
like Ser876, Thr1010, Phen914, Phe1009 and Phe649 and its close proximity to dioxothiomolybdenum (MOS). Biotage 微波合成仪 Initiator+ Biotage 微波合成仪 Initiator Biotage 微波合成仪 Initiator+ Robot 8 Biotage 微波合成仪 Initiator+ Robot 60
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