Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

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2024-09-28 00:49 298阅读次数

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Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

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Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes[详细]
2024-09-28 00:49
应用文章
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Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dy

Titaniumdioxide(TiO2)nanoparticlesareoneofthemosthighlymanufacturednanomaterialsintheworldwithapplicationsincopiousindustrialandconsumerproducts.Theliverisamajoraccumulationsiteformanynanoparticles,includingTiO2,directlythroughintentiona领estionorindirectlythroughincreasedenvironmentalcontaminationandunintentiona领estionviawater,foodoranimals.GrowingconcernsoverthecurrentusageofTiO2coupledwiththelackofmechanisticunderstandingofitspotentialhealthriskisthemotivationforthisstudy.HerewedeterminedthetoxiceffectofthreedifferentTiO2nanoparticles(commerciallyavailablerutile,anataseandP25)onprimaryrathepatocytes.Specifically,weevaluatedeventsrelatedtohepaticfunctionsandmitochondrialdynamics:(1)ureaandalbuminsynthesisusingcolorimetricandELISAassays,respectively;(2)redoxsigna领mechanismsbymeasuringROSproduction;(3)OPA1andMfn-1expressionthatmediatesthemitochondriadynamicsbyPCR;and(4)mitochondrialmorphologybyMitoTrackerGreenFMstaining.AllthreeTiO2nanoparticlesinducedasignificantlossinhepaticfunctionsevenatconcentrationsaslowas20μg/mlwithcommerciallyusedP25causingmaximumdamage.TiO2nanoparticlesinducedastrongoxidativestressinprimaryhepatocytes.TiO2nanoparticlesexposurealsoresultedinmorphologicalchangesinmitochondriaandsignificantlossinthefusionprocess,thusimpairingthemitochondrialdynamics.AlthoughthisstudydemonstratedthatTiO2nanoparticlesexposureresultedinsignificantdamageinprimaryhepatocytes,moreinvitroandinvivostudiesarerequiredtodeterminethecompletetoxicologicalmechanismonprimaryhepatocytesandsubsequentlyliverfunction.[详细]
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SuitableanalyzersnON900nONH2000UsedaccessoriesnInnergraphitecrucibles(90180)nOutergraphitecrucibles(90185)nNickelbasket(90250)orAR2344nSuitablecalibrationmaterial(NISTorother)SettingsnComparatorlevel:20mVnMinimumtime:15secnMaximumtime:3:00minnPostwaiting:30secnBaselinedeviation:200mV;Step:16mV;Time:10secnMode:continuousnOutgasTime:45secPower:6kWnTimePurge:20secStability:45secnIntegrationdelayIRcell:2secTCcell:10secnAnalyse(1)Time:75secPower(1):6kWPower(2):6kWSamplepreparationMakesurethatthesurfaceofthetitaniumisfreefromcontaminations;otherwisecleanthesamplewithacetonep.a.andletdryatatmosphere.ProcedurenPrepareELTRAanalyzer(exchangeanhydrone,sodiumhydroxide,copperoxidewhennecessary),cleanfurnace,sampledropmechanism,electrodetipnRunthreeblankswithemptycruciblesnCalibratetheanalyzerwithsuitablecalibrationmaterial(NISTorother)(1)Filloneemptyinnercrucible(90180)inoneoutercrucible(90185)andplacethemontheelectrodetip,closefurnace(F2Button)(2)Weighcalibrationmaterialandgiveitintoanickelbasket(90250orAR2344)(3)Placenickelbasketwithcalibrationmaterialorsampleinthesampledropmechanismandstartanalysis(F5Button)Afteranalysisgivetheinnercrucibleintowasteandfillinanewone.Theoutercruciblescanbeusedapproximately10times.Repeatsteps(1)(3)atleastthreetimes;Marktheresultsandusethecalibrationfunctioninthesoftware.[详细]
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Titanium Dioxide Nanoparticles Trigger Loss of Hepatic Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes

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