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仪器网>产品中心> 翌圣生物科技(上海)股份有限公司>重组蛋白1>抗体药物靶点蛋白>Recombinant Human CDH17/Cadherin 17 (His Tag)

Recombinant Human CDH17/Cadherin 17 (His Tag)

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翌圣生物 2026-04-20 16:48:44
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产品详情:

 

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. 


产品性质

别名

Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024

Uniprot No.

Q12864.1

表达区间及表达系统

Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Gln23-Met787.

分子量

Approximately 86.1 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.

纯度

> 95% as determined by SDS-PAGE and HPLC.

活性

ELISA DataImmobilized Human CDH17, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA.

内毒素

1.0 EU per 1μg of the protein by the LAL method.

制剂

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

复溶

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.


运输与保存方法

冰袋运输-20-80存,一年有效期

复溶后,-20 -80°C,在未开封状态下保存 3-6 个月复溶后,2-8°C 保存 2-7 天。

建议第一次使用时分装存,避免反复冻融

 

 注意事项

1. 避免反复冻融。

2. 为了您的安全和健康,请穿实验服并戴一次性手套操作。

3. 本产品仅作科研用途!


产品数据

image.png

HB220810

 

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