细节创新，全面升级——玉研仪器重磅更新小动物脑立体定位仪

• 数显大屏，触屏使用——直接读取坐标

• 调零功能，方便操作——任意位置均可清零

• 经典设计，精准操控——十字臂升级为三杆固定，双侧贯通，精准稳固

• 精良工艺，保驾护航——新增螺旋调节耳杆，微米级位移细调，定位更准确

• 经典设计，精准操控——经典U型底座设计，外观简洁、精巧，安装和调节方便、灵活

• 三轴移动，自由旋转——水平方向360°，垂直方向180°旋转并随时锁定任意位置

• 多选择，高适配——可选配不同动物适配器

• 轻便设计，操作简便——组件减少，轻量化设计，安装简便

• 改良设计，精准操控——可移动组件前后左右移动代替传统的“U”型支架

• 多选择，高适配——门齿夹组件大小鼠可以互换

设备标配电极夹持器，并可选配多种类型夹持器，如标准夹持器、通用夹持器、注射泵夹持器、颅钻夹持器、套管夹持器、放大器夹持器等，从而完成打孔、颅内注射、电极植入等一系列手术操作。

（二）不同规格小动物适配器

（三）小动物颅骨钻

1.Li, Qiuying et al. “Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury.” Neuroscience vol. 545 (2024): 111-124. doi:10.1016/j.neuroscience.2024.03.009

2.Wang, Chaoyu et al. “Tetramethylpyrazine protects mitochondrial function by up-regulation of TFAM and inhibition of neuronal apoptosis in a rat model of surgical brain injury.” Iranian journal of basic medical sciences vol. 27,3 (2024): 352-359. doi:10.22038/IJBMS.2023.72947.15862

3.Duan, R., Hong, C. G., Chen, M. L., Wang, X., Pang, Z. L., Xie, H., & Liu, Z. Z. (2023). Targeting autophagy receptors OPTN and SQSTM1 as a novel therapeutic strategy for osteoporosis complicated with Alzheimer's disease. Chemico-Biological Interactions, 377, 110462.

4.Xia, Pengcheng et al. “MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus.” Journal of neuroinflammation vol. 19,1 180. 12 Jul. 2022, doi:10.1186/s12974-022-02548-1

5.Chen, Meng-Lu et al. “Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy.” Theranostics vol. 11,5 2395-2409. 1 Jan. 2021, doi:10.7150/thno.47408

6.Shen, Jie et al. “PDGFR-beta signaling mediates endogenous neurogenesis after postischemic neural stem/progenitor cell transplantation in mice.” Brain injury vol. 37,12-14 (2023): 1345-1354. doi:10.1080/02699052.2023.2280894

7.Wu, Muyao et al. “The Blood Component Iron Causes Neuronal Apoptosis Following Intracerebral Hemorrhage via the PERK Pathway.” Frontiers in neurology vol. 11 588548. 7 Dec. 2020, doi:10.3389/fneur.2020.588548

8.Jiang C, Wu X, Wang J, Li C, Luo G. Activation of CB1 pathway in the perirhinal cortex is necessary but not sufficient for destabilization of contextual fear memory in rats. Behavioural Brain Research. 2022;416:113573.

9.Liu Z, Li H, Hong C, et al. ALS-associated E478G mutation in human OPTN (Optineurin) promotes inflammation and induces neuronal cell death. Frontiers in immunology. 2018;9:2647.

10.Zhang Z, Chen W, Luan J, Chen D, Liu L, Feng X. Ameliorative effects of olibanum essential oil on learning and memory in Aβ1-42-induced Alzheimer’s disease mouse model. Tropical Journal of Pharmaceutical Research. 2020;19(8):1643-1651.

11.Wang Y, Zhang H, Hua L, et al. Curcumin prevents Alzheimer’s disease progression by upregulating JMJD3. American Journal of Translational Research. 2022;14(8):5280.

12.Shi M, Gong Y, Wu M, et al. Downregulation of TREM2/NF-кB signaling may damage the blood-brain barrier and aggravate neuronal apoptosis in experimental rats with surgically injured brain. Brain Research Bulletin. 2022/06/01/ 2022;183:116-126.

13.Zhang B-J, Yuan C-X. Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats. Biomedicine & Pharmacotherapy. 2019/01/01/ 2019;109:217-225.

14.Chen ML, Hong CG, Yue T, et al. Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy. Theranostics. 2021;11(5):2395-2409.

15.Gong Y, Wu M, Shen J, et al. Inhibition of the NKCC1/NF-κB signaling pathway decreases inflammation and improves brain edema and nerve cell apoptosis in an SBI rat model. Frontiers in Molecular Neuroscience. 2021;14:641993.

16.Zhang D, Pan N, Jiang C, Hao M. LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke. Journal of Leukocyte Biology. 2022/05/01 2022;111(5):953-966.

17.Zhou G, Ye Q, Xu Y, et al. Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction. International Immunopharmacology. 2023/04/01/ 2023;117:109614.

18.Liu FX, Niu YG, Zhang DP, et al. Modified Protocol for Establishment of Intracranial Arterial Dolichoectasia Model by Injection of Elastase Into Cerebellomedullary Cistern in Mice. Frontiers in Neurology. 2022:748.

19.Xu Z, Lu W, Miao Y, Li H, Xie X, Zhang F. mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice. International Immunopharmacology. 2020;87:106792.

20.Hu WB, Wang X, Pang ZL, Duan R, Hong CG, Liu ZZ. Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus‐infected OPTNE478G mouse model. Animal Models and Experimental Medicine. 2022.

21.Jiao, Yingfu et al. “Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors.” Experimental cell research vol. 418,1 (2022): 113224. doi:10.1016/j.yexcr.2022.113224

22.Liu, Yamei et al. “Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats.” Epilepsy & behavior : E&B vol. 106 (2020): 106894. doi:10.1016/j.yebeh.2019.106894

23.Huang S, Hu W, Rao D, et al. RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage. Journal of Stroke and Cerebrovascular Diseases. 2022;31(1):106213.