【THUNDER小课堂】血管疾病的分子机制

结

论

1.V. Nanda, T. Wang, M. Pjanic, B. Liu, T. Nguyen, L. Perisic Matic, U. Hedin, S. Koplev, L. Ma, O. Franzén, A. Ruusalepp, E.E. Schadt, J.L.M. Bj?rkegren, S.B. Montgomery, M.P. Snyder, T. Quertermous, N.J. Leeper, C.L. Miller, Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus, PLOS Genet. (2018) vol. 14, no. 11, e1007755, DOI: 10.1371/journal.pgen.1007755.

2.Y. Wang, H. Gao, F. Wang, Z. Ye, M. Mokry, A.W. Turner, J. Ye, S. Koplev, L. Luo, T. Alsaigh, S.S. Adkar, M. Elishaev, X. Gao, L. Maegdefessel, J.L.M. Bj?rkegren, G. Pasterkamp, C.L. Miller, E.G. Ross, N.J. Leeper, Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells, Cardiovascular Research (2021) cvab347, DOI: 10.1093/cvr/cvab347.

3.Y. Kojima, J. Ye, V. Nanda, Y. Wang, A.M. Flores, K.-U. Jarr, P. Tsantilas, L. Guo, A.V. Finn, R. Virmani, N.J. Leeper, Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis, Circulation (2020) vol. 141, pp. 1274–1276, DOI: 10.1161/CIRCULATIONAHA.119.043413.

4.J. Schumacher, L. Bertrand, THUNDER Technology Note: THUNDER Imagers: How Do They Really Work? Science Lab (2019) Leica Microsystems. 

5.L. Felts, V. Kohli, J.M. Marr, J. Schumacher, O. Schlicker, An Introduction to Computational Clearing: A New Method to Remove Out-of-Focus Blur, Science Lab (2020) Leica Microsystems. 

的历史最 早可追溯到19世纪，作为德国著名的光学制造企业，徕卡显微成像系统拥有170余年显微镜生产历史，逐步发展成为显微成像系统行业的领先的厂商之一。徕卡显微成像系统一贯注重产品研发和最 新技术应用，并保证产品质量一直走在显微镜制造行业的前列。

始终与科学界保持密切联系，不断推出为客户度身定制的显微解决方案。徕卡显微成像系统主要分为三个业务部门：生命科学与研究显微、工业显微与手术显微部门。徕卡在欧洲、亚洲与北美有7大产品研发中心与6大生产基地，在二十多个国家设有销售及服务分支机构，总部位于德国维兹拉(Wetzlar)。