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Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development. Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail. In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration.
产品性质
|
别名 |
VCL; Vinculin; Metavinculin |
|
SwissProt ID |
P18206 |
|
基因ID |
7414 |
|
免疫原 |
Recombinant protein of human Vinculin |
|
缓冲液 |
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
|
分子量 |
Calculated MW: 124 kDa; Observed MW:124 kDa |
|
克隆类型 |
Monoclonal Antibody |
|
宿主 |
Rabbit |
|
物种反应 |
Human, Mouse, Rat |
|
推荐应用 |
WB, IHC-P |
|
纯化方式 |
Affinity Purified |
应用
稀释比 WB:1/500-1/1000;IHC: 1/50-1/100;
储存条件
-25~-15℃保存
注意事项
1. 避免反复冻融。
2. 本产品仅作科研用途。
2. 为了您的安全和健康,请穿实验服并佩戴一次性手套操作。
产品数据
Western blot

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