BCEIA 2023 ‖ 大会报告特邀专家——Prof. K. W. Michael SIU

Prof. K.W.Michael SIU

University of Windsor

报告题目：Linkage between the Environment and Health: Impact of Environmental Factors on Individual’s Health and Expressed in Changes in their Proteome

报告摘要

According to the World Health Organization (WHO), over 90% of cancer incidence is closely associated with environmental pollution. Carcinogenic transformation is typically a multistep process that sees cells progress from normal, to pre-cancerous, and finally to the cancerous stage. This progression reflects molecular changes within the cells as a result of interaction between genes and pollutants. Common viruses, including the Epstein-Barr Virus (EBV) and the human papillomavirus (HPV), are environmental factors that impact upon specific cancer incidence. It is noteworthy that incidence of cancer in the world exhibits national and regional differences that are likely to reflect the interplay between genetic and environmental factors. In the U.S., oral cancer is by far the most prominent head and neck cancer; nasopharyngeal cancer (NPC)’s incidence is only 8% of that of oral cancer. By contrast, in China NPC outpaces oral cancer by 200%. Even within China, NPC is largely concentrated in the southeastern regions, including Guangdong and Hong Kong. This highly regional distribution of NPC incidence emphasizes the importance of environmental contribution. This contribution and impact to the proteome will be explored and discussed.

个人简介

Siu is Professor of Chemistry and Biochemistry at the University of Windsor. Prior to his appointment at Windsor, Siu was Distinguished Research Professor (2007 – 2014) and NSERC / SCIEX Senior Industrial Research Chair in Analytical Mass Spectrometry (1998 – 2012) at York University. Siu has published > 290 papers (Google Scholar, July 18, 2023: h-index, 68; i10-index, 234; total citations, 14,306; # papers cited ≥ 100 times, 40) and has given > 500 presentations, of which > 50% are in the invited, keynote and plenary category. He is a Fellow of the Chemical Institute of Canada and the Royal Society of Canada. Siu has received multiple awards, as well as funding and grants from many agencies and organizations totalling > $ 22 million. The oral cancer biomarkers that Siu and his collaborators and identified have now been commercialized and offered as a prognostic test (Straticyte: www.proteocyte.com) for lesions that may transform into cancers.

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