一种包裹白藜芦醇复合物的功效性及其透皮能力

摘要:

研究了一种可溶于水的包裹白藜芦醇复合物（encapsulated resveratrol，eRES）的功效，其组成为 8% 白藜芦醇（RES），壁材为 91% 磺丁基 -β- 环糊精和 1% 聚季铵盐 -51，含量均为质量分数。利用生化方法、斑马鱼模、蘑菇酪氨酸酶等试验模型，对 eRES 和纯 RES（pure RES，pRES）的抗氧化、抗炎舒缓、抑制酪氨酸酶活性进行对比 ；在成纤维细胞模型上研究了 eRES 对胶原蛋白生成的影响，并进一步研究了 eRES 的透皮吸收特性。结果表明，在相同RES 含量时，eRES 具有和 pRES 相近的抗氧化、抗炎舒缓和抑制酪氨酸酶活性，同时 eRES 可促进胶原蛋白的合成，并进一步验证了 eRES 的透皮吸收能力。试验也同时揭示了，作为壁材磺丁基 -β- 环糊精和聚季铵盐 -51，对所包裹原料功效影响较小，这对其未来作为壁材原料起到参考作用。

关键词：

白藜芦醇 包合物 抗氧化 抗炎舒缓 透皮吸收

Activities and Transdermal Research of Resveratrol Inclusion Complex

YUAN Minjia1,2 CHENG Weifeng3 ZHU Cuicui1,2#

(1. Shanghai Qiran Biotechnology Co., Ltd., Shanghai 201702, China; 2. Shanghai Jinjia Technology Co.,Ltd., Shanghai 201210, China; 3. Shanghai Oli Enterprises Co., Ltd., Shanghai 201401, China)

Abstract: A water-soluble encapsulated resveratrol complex (eRES) containing 8% resveratrol (RES), 91% sulfobutyl-β-cyclodextrin and 1% ( all in mass fraction) polyquaternary ammonium salt-51 as wall materials was studied. Biochemicalmethods, zebrafish models and mushroom tyrosinase models were used to compare the anti-oxidant, anti-inflammatory and inhibitory activities of eRES and pure RES (pRES). The effect of eRES on collagen production on fibroblast model and the transdermal absorption of eRES were studied. The results showed that eRES, at the same RES concentration, had similar anti-oxidant, anti-inflammatory soothing and tyrosinase inhibitory activities as pRES. Meanwhile, eRES could promote the synthesis of collagen. The transdermal absorption capacity of eRES was further verified. This study also revealed that sulfobutyl-β-cyclodextrin and polyquat ernary ammonium salt-51, as wall materials, had little effect on the efficacy of the coated raw materials, which would provide a reference for their future use as wall materials.

Keywords: resveratrol encapsulated complex anti-oxidation anti-inflammatory transdermal absorption